Journal: Evidence-based Complementary and Alternative Medicine : eCAM

Article Title: Anti-Lung-Cancer Activity and Liposome-Based Delivery Systems of β -Elemene

doi: 10.1155/2012/259523

Figure Lengend Snippet: Chemical structure of β -Elemene.

Article Snippet: Afterwards, an injection preparation containing 85% β -elemene developed by CSPC Pharmaceutical Limited Cooperation (China) has been approved by the SFDA, China, for the treatment of brain tumours and other carcinomas [ ].

Techniques:

Journal: Oncology Reports

Article Title: β-elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A-VEGFA pathway based on network pharmacology

doi: 10.3892/or.2019.7360

Figure Lengend Snippet: Network of β-elemene-target genes. Red diamond represents β-elemene; blue circles represent target genes of β-elemene.

Article Snippet: Serial concentrations of β-elemene [CSPC Pharmaceutical Group Company Ltd. (YUANDA), Dalian, China] were added to the cells: 0, 0.5, 1, 2, 4, 8 and 16 µM.

Techniques:

Journal: Oncology Reports

Article Title: β-elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A-VEGFA pathway based on network pharmacology

doi: 10.3892/or.2019.7360

Figure Lengend Snippet: Thirty-three target genes for β-elemene against pancreatic cancer. (A) Venn diagram revealing the overlapping target genes for β-elemene against pancreatic cancer. (B) Network of target genes for β-elemene against pancreatic cancer. Red diamond represents β-elemene; red hexagon represents pancreatic cancer; blue circles represent target genes of both β-elemene and pancreatic cancer; yellow triangles represent KEGG pathway analysis of 33 target genes based on the DAVID database. KEGG, Kyoto encyclopedia of genes and genomes; DAVID, Database for Annotation, Visualization and Integrated Discovery.

Article Snippet: Serial concentrations of β-elemene [CSPC Pharmaceutical Group Company Ltd. (YUANDA), Dalian, China] were added to the cells: 0, 0.5, 1, 2, 4, 8 and 16 µM.

Techniques:

Journal: Oncology Reports

Article Title: β-elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A-VEGFA pathway based on network pharmacology

doi: 10.3892/or.2019.7360

Figure Lengend Snippet: Molecular docking simulation of β-elemene to HIF1A. Sticks represent the three-dimensional structure of β-elemene; surface represents the protein structure of HIF1A. HIF1A, hypoxia-inducible factor 1-α.

Article Snippet: Serial concentrations of β-elemene [CSPC Pharmaceutical Group Company Ltd. (YUANDA), Dalian, China] were added to the cells: 0, 0.5, 1, 2, 4, 8 and 16 µM.

Techniques:

Journal: Oncology Reports

Article Title: β-elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A-VEGFA pathway based on network pharmacology

doi: 10.3892/or.2019.7360

Figure Lengend Snippet: Antitumor effect of β-elemene in pancreatic cancer. (A) MTT assay revealed that cell viability was suppressed by β-elemene in PANC-1 cells in a dose-dependent manner. (B) MTT assay revealed that cell viability was suppressed by β-elemene in BxPC3 cells in a dose-dependent manner. (C and D) MTT assay revealed that cell viability was suppressed by β-elemene in cells isolated from peritoneum effusion of pancreatic cancer patients in a dose-dependent manner.

Article Snippet: Serial concentrations of β-elemene [CSPC Pharmaceutical Group Company Ltd. (YUANDA), Dalian, China] were added to the cells: 0, 0.5, 1, 2, 4, 8 and 16 µM.

Techniques: MTT Assay, Isolation

Journal: Oncology Reports

Article Title: β-elemene inhibits the generation of peritoneum effusion in pancreatic cancer via suppression of the HIF1A-VEGFA pathway based on network pharmacology

doi: 10.3892/or.2019.7360

Figure Lengend Snippet: Validation of the HIF1A-VEGFA pathway inhibited by β-elemene in pancreatic cancer. (A) Western blot analysis in PANC-1 and BxPC3 pancreatic cancer cell lines and (B) corresponding histogram of protein expression levels of HIF1A and VEGFA in PANC-1 and BxPC3 pancreatic cancer cells. Three independent biological replicates were performed and data are presented as the mean ± standard deviation. *P<0.05 and **P<0.01. NS, not significant. HIF1A, hypoxia-inducible factor 1-α; VEGFA, vascular endothelial growth factor A.

Article Snippet: Serial concentrations of β-elemene [CSPC Pharmaceutical Group Company Ltd. (YUANDA), Dalian, China] were added to the cells: 0, 0.5, 1, 2, 4, 8 and 16 µM.

Techniques: Western Blot, Expressing, Standard Deviation